Rely on Rune. If you're doing well and your luck isn't shit you should be able to recharm/get the situation under control before Rune breaks, or before you take more than 10% damage post break. Get a Mystical Cloak for a clicky Steelskin which can save your life if you run out of components for Rune on the job. Keep bandages on yourself. Do the quest in FV for Visions of Sebilite for Ikky regen.
Even better: make friends with a cleric and duo.
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