Depending on where you fight you'll inevitably run into quests. Fighting in Crushbone (lvls 9ish-16/17) for example will net you Crushbone Belts which can be turned into to a gentleman in Kaladim for exp. Things like that are really the only quests worth doing, where the mobs you're grinding provide you with the means to do the quest and then you just turn in when your done for the night or bags are full whatever.
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